Autophagy and Human Parturition: Evaluation of LC3 Expression in Placenta from Spontaneous or Medically Induced Onset of Labor
Figure 4
Autophagy and clinical correlation. (a) A significant correlation was found between LC3-II expression and prepregnancy maternal body mass index. Open circles: spontaneous onset of labor; closed circles: pharmacological induction of labor. LC3-II = 3.6–0.11 BMI. 0.29. . (b) LC3 dots formation identified by immunofluorescence in two cases of our population. Lower panel: PG group, patient with BMI = 16.6 kg/m2, LC3-II/α tubulin = 2.07, and umbilical cord pH = 7.22. Upper panel: PG group, patient with BMI = 26.6 kg/m2, LC3-II/α tubulin = 1.0, and umbilical cord pH = 7.25. (c) No relationship was found between maternal pre-pregnancy BMI and pH in umbilical cord. Open circles: spontaneous onset of labor; closed circles: pharmacological induction of labor. (d) No relationship was found between autophagy and pH in umbilical cord. Open circles: spontaneous onset of labor; closed circles: pharmacological induction of labor. (e) No relationship was found between autophagy and pO2 (mmHg) in umbilical cord. Open circles: spontaneous onset of labor; closed circles: pharmacological induction of labor. BMI: body mass index.
