N-Acetylcysteine Prevents Hypertension via Regulation of the ADMA-DDAH Pathway in Young Spontaneously Hypertensive Rats

Table 1

Weights and functional parameters.

	WKY	SHR	SHR + NAC
Body weight (g)	294.6±4.0	308.1±4.5	286.9±3.4^#
Heart weight (g)	1.16±0.06	1.38±0.03^∗	1.20±0.03^#
Heart weight per 100 g body weight	0.39±0.02	0.45±0.01^∗	0.42±0.01
Left kidney weight (g)	1.19±0.05	1.36±0.07	1.25±0.04
Left kidney weight per 100 g body weight	0.40±0.02	0.44±0.02	0.43±0.01
UNOxV (μmole·24 hr^−1·100 g BW^−1)	1.16±0.21	0.34±0.15^∗	0.69±0.11^#

SHR + NAC, spontaneously hypertensive rat treated with N-acetylcysteine; 𝑛=8 per group; UNO_xV, total urinary NO_x (NO₃⁻+NO₂⁻) excretion. ^∗𝑃<0.05 SHR versus WKY; ^#𝑃<0.05 SHR + NAC versus SHR.