In Silico Screening and Molecular Dynamics Simulation of Disease-Associated nsSNP in TYRP1 Gene and Its Structural Consequences in OCA3

Table 2

The disease associated SNPs are predicted from PHDsnp, SNP&GO, and Pmut servers.

SNP IDs	Mutation	PHDsnp results	SNP&GO	Pmut
				Score	Prediction
rs201345670	M266T	Neutral	Disease	0.4759	Neutral
rs201293896	R146W	Disease	Disease	0.6728	Pathological
rs200754545	W249G	Neutral	Disease	0.5638	Pathological
rs193035382	C303G	Disease	Disease	0.2516	Neutral
rs188236569	Y522C	Neutral	Disease	0.6752	Pathological
rs149856598	G309E	Disease	Disease	0.8774	Pathological
rs149324507	V189L	Disease	Disease	0.4793	Neutral
rs148248971	A409V	Disease	Disease	0.4533	Neutral
rs143106698	F383L	Disease	Disease	0.3564	Neutral
rs141949653	N435H	Disease	Disease	0.1202	Neutral
rs139946740	G309R	Disease	Disease	0.6503	Pathological
rs113146199	D343V	Disease	Disease	0.5798	Pathological
rs78071458	G174L	Disease	Disease	0.3075	Neutral
rs61752939	T262M	Disease	Disease	0.6624	Pathological
rs61752937	R93H	Disease	Disease	0.6320	Pathological
rs35197549	V319G	Disease	Disease	0.2561	Neutral
rs16929374	R326H	Disease	Disease	0.9314	Pathological
VAR_068176	R93C	Disease	Disease	0.1465	Neutral
VAR_026828	R356Q	Disease	Disease	0.6210	Pathological

Disease associated SNPs are displayed in bold.