Characterization of C-S Lyase from C. diphtheriae: A Possible Target for New Antimicrobial Drugs

Figure 5

Superimposed structures of C-S lyase from Corynebacterium diphtheriae and cystalysin from Treponema denticola. (a) A subunit of C-S lyase (green) with a portion of chain B (orange) is superimposed with chains A and B of cystalysin (in pink and blue, resp.). (b) A close-up of the active site with the AVG inhibitor (in gray) is shown. Residues conserved in both proteins are shown in red. Phe273 is presented only in the chain B of cystalysin and is depicted in cyan, while residues Lys230 and Asp88 are presented only in C-S lyase and are shown in yellow. Residue numbers are indicated as cystalysin/C-S lyase. An asterisk (*) indicates that the residues are present only in chain B.