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BioMed Research International
Volume 2013, Article ID 709037, 6 pages
Research Article

A Comparison between 18F-FDG PET/CT Imaging and Biological and Radiological Findings in Restaging of Hepatoblastoma Patients

1Positron Emission Tomography Centre, IRMET S.p.A., Euromedic Inc., 10136 Turin, Italy
2Co-ordinator of PET Pediatric AIMN InterGroup, 10136 Turin, Italy
3Associate researcher of Institute of Cognitive Sciences and Technologies, National Research Council, 00185 Rome, Italy
4Department of Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland
5Pediatric Unit, Hospital Cirie' ASL To4, 10073 Cirie' (TO), Italy
6Department of Radiological Sciences, HSR Giglio, 90015 Cefalù (PA), Italy
7Paediatric Oncohematologic Unit, Department of Paediatric Oncology, Regina Margherita Children’s Hospital, 10126 Turin, Italy
8Department of Haematology, Oncology, Immunology and Infectious Diseases, Regina Margherita Children’s Hospital, 10126 Turin, Italy
9Nuclear Medicine Unit, La Maddalena Hospital, 90146 Palermo, Italy
10Nuclear Medicine Unit, Department of Biomedical Sciences and of Morphologic and Functional Images, University of Messina, 98125 Messina, Italy

Received 29 April 2013; Accepted 20 July 2013

Academic Editor: Sherif Heiba

Copyright © 2013 Angelina Cistaro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. In this study we retrospectively evaluated if 18F-FDG-PET/CT provided incremental diagnostic information over CI in a group of hepatoblastoma patients performing restaging. Procedure. Nine patients (mean age: 5.9 years; range: 3.1–12 years) surgically treated for hepatoblastoma were followed up by clinical examination, serum -FP monitoring, and US. CI (CT or MRI) and PET/CT were performed in case of suspicion of relapse. Fine-needle aspiration biopsies (FNAB) were carried out for final confirmation if the results of CI, PET/CT, and/or -FP levels were suggestive of relapse. PET/CT and CI findings were analyzed for comparison purposes, using FNAB as reference standard. Results. -FP level was suggestive of disease recurrence in 8/9 patients. Biopsy was performed in 8/9 cases. CI and PET/CT resulted to be concordant in 5/9 patients (CI identified recurrence of disease, but 18F-FDG-PET/CT provided a better definition of disease extent); in 4/9 cases, CI diagnostic information resulted in negative findings, whereas PET/CT correctly detected recurrence of disease. 18F-FDG-PET/CT showed an agreement of 100% (8/8) with FNAB results. Conclusions. 18F-FDG-PET/CT scan seems to better assess HB patients with respect to CI and may provide incremental diagnostic value in the restaging of this group of patients.