Formulation Development and Evaluation of Hybrid Nanocarrier for Cancer Therapy: Taguchi Orthogonal Array Based Design
Figure 9
Figure showing stability of various formulations: (a) C-ANC-G, (b) M-ANC-G, (c) C-HNC-G, and (d) M-HNC-G with respect to size (nm) and zeta potential (mV) under influence of varying pH between 7.4 and 5.4. C-ANC-G and C-HNC-G represent gemcitabine loaded albumin nanocarrier and hybrid nanocarrier, respectively, formulated using conventional method, while M-ANC-G and M-HNC-G represent gemcitabine loaded albumin nanocarrier and hybrid nanocarrier, respectively, formulated using method modified using Taguchi orthogonal array design method. Dashed circle highlights significant changes in size of nanocarriers at pH 5.4. Results are represented as mean SD ().
