Temperature and Drug Treatments in Mevalonate Kinase Deficiency: An Ex Vivo Study

Table 3

Levels of cytokines tested in the LPS, LPS + GOH, and LPS + Typ treated MKD patients’ monocytes, both at 37°C and 40°C.

Cytokine	Patients’ monocytes
	37°C			40°C
	LPS	LPS + GOH^a	LPS + Typ^b	LPS	LPS + GOH^a	LPS + Typ^b
IL-1β	1235±146.2	657±283.6	1040±73	494.3±165.8	210.8±93.1	343±106.4
IL-1ra	864.6±117.4	632.9±109.6	808.6±100.6	769.4±47.1	610.6±108.5	724.1±34.2
IL-2	114.8±3.3	97.1±9.1	107.2±1.1	107.3±5	92.7±4.1	103.1±6.1
IL-4	13.8±0.6	11.5±1.5	13.6±0.5	12.8±0.9	10.3±1.1	12±1.3
IL-6	21756±3518	17544±6648	20633±3314	19145±2204	12071±4108	18614±2803
IL-9	197.3±13.3	168.8±14.5	190.6±6.5	192.1±8.6	167.7±26.7	181.2±6.5
IL-12(p70)	89.3±11	65±5.8	81.2±4.2	68.9±4.1	70±2	69.3±5.8
IL-15	185.4±5.3	166.3±8.9	177.6±4.6	176.3±3.2	168.8±6.4	176.3±4.4
IL-17	500.3±11.4	427.1±35	478.7±22.4	495.6±24.5	422.7±21.8	465.3±16.4
Eotaxin	216.5±5	186.1±16.6	211.2±3.2	205.9±11.2	187.6±8.2	201±11.6
FGF-basic	262.2±2.2	231.4±13.1	250.2±6.2	251.1±10.5	220.5±8.1	242.2±7.6
IFN-γ	324.3±10.3	270.5±34.7	310.6±13.6	308.6±15.7	244.6±26.4	288.8±16.9
IP-10	146.2±5.8	125.7±14.2	145.7±6.4	131.3±3.2	113.8±10.5	129.7±7.6
MIP-1α	8980±1899	5308±2213	8306±1780	8234±963.1	4675±1792	7854±1155
PDGF-BB	129.6±3	107.6±8.6	123.2±8.2	112.7±2.7	97.4±11.2	107.9±5.2
VEGF	116.3±11.5	96.4±8.6	115.2±10.1	106.4±5.8	67.8±13.7	112.9±8.8

Values are expressed as mean ± SEM, in pg/mL; ^ageraniol; ^bTipifarnib.