Research Article
Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets
Table 6
Coefficients of determination (
) obtained from dissolution of norfloxacin coated formulations according to different mathematical models.
| Formulation | Zero order | First order | Higuchi | Korsmeyer-Peppas | | | | | |
| HPMC K100LV 20% | 0.9827 | 0.9719 | 0.9649 | 0.9990 | 0.9283 | HPMC K100LV 30% | 0.9898 | 0.9571 | 0.9588 | 0.9999 | 0.8867 | HPMC K4M 20% | 0.9833 | 0.9981 | 0.9807 | 0.9998 | 0.7270 | HPMC K4M 30% | 0.9784 | 0.9921 | 0.9821 | 0.9984 | 0.7041 | PEO N60K 20% | 0.9759 | 0.9716 | 0.9685 | 0.9975 | 0.9892 | PEO N60K 30% | 0.9955 | 0.9766 | 0.9468 | 0.9992 | 1.0019 | PEO 301 20% | 0.9970 | 0.9593 | 0.9277 | 0.9979 | 0.8522 | PEO 301 30% | 0.9911 | 0.9586 | 0.9216 | 0.9917 | 0.8550 |
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