Research Article

Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets

Table 6

Coefficients of determination ( ) obtained from dissolution of norfloxacin coated formulations according to different mathematical models.

FormulationZero orderFirst orderHiguchiKorsmeyer-Peppas

HPMC K100LV 20% 0.98270.97190.96490.99900.9283
HPMC K100LV 30% 0.98980.95710.95880.99990.8867
HPMC K4M 20% 0.98330.99810.98070.99980.7270
HPMC K4M 30% 0.97840.99210.98210.99840.7041
PEO N60K 20% 0.97590.97160.96850.99750.9892
PEO N60K 30% 0.99550.97660.94680.99921.0019
PEO 301 20% 0.99700.95930.92770.99790.8522
PEO 301 30% 0.99110.95860.92160.99170.8550