CXCR1/CXCR2 Antagonism Is Effective in Pulmonary Defense against Klebsiella pneumoniae Infection

Figure 2

Comparison of different treatments for inflammatory pathology in guinea pigs with Klebsiella pneumoniae. The lungs of the control group were normal in gross appearance, while the lungs of the bacterial control group were markedly hemorrhagic and congested. The G31P-treated group was largely free of hemorrhagic consolidation and had greatly reduced pulmonary inflammation. The lungs of the saline controls exhibited a normal histological appearance, while the lungs of the bacterial control animals were markedly hemorrhagic and congested with red blood cells (RBC) and neutrophils (PMN).