Review Article
Fermentative Succinate Production: An Emerging Technology to Replace the Traditional Petrochemical Processes
Table 3
Comparison of different downstream processing strategies for succinate separation and purification.
| Downstream processing strategies | Advantages | Disadvantages |
| Crystallization | Easy to be operated; without additional reagents. | Low succinate yield and purity; recrystallization is required. | Precipitation | Low technological barriers; inexpensive precipitants. | Requirement of large quantities of precipitants; generation of useless by-products. | Extraction | High output and low energy consumption. | Pretreatment of the fermentation broth is required; expensive extraction agents used for reactive extraction. | Electrodialysis | Relatively mild conditions; can be used for continuous separation. | High energy consumption; high cost of the membranes; low selectivity for succinate. | Chromatography | Easy to be scaled up. | Regeneration of the chromatographic matrix requires large amounts of acids and alkalis. | In situ separation | Can be coupled with the fermentation process; relieving product inhibition. | Relatively complicated processes; regeneration of separation sorbent is required. |
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