Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin

Table 1

Composition of the developed alginate-carrageenan hydrogel microparticles encapsulating curcumin-loaded chitosan nanoparticles and its influence on the particle size.

Formulation code	Drying	Curcumin-loaded chitosan particles (mL)	Alginate (w%)	Carrageenan (w%)	CaCl2 (%)	KCl (%)	Average geometric size (𝜇m) ± SD
F1	FD	20	100	0	3	3	1034±0.1
	AD	20	100	0	3	3	831±0.1
F2	FD	20	70	30	3	3	1210±0.2
	AD	20	70	30	3	3	1026±0.1
F3	FD	20	50	50	3	3	2064±0.2
	AD	20	50	50	3	3	1171±0.3

FD: freeze-dried, AD: air-dried.