Ubiquitin Ligase Cbl-b Is Involved in Icotinib (BPI-2009H)-Induced Apoptosis and G1 Phase Arrest of EGFR Mutation-Positive Non-Small-Cell Lung Cancer
Icotinib-induced G1 phase cell cycle arrest in HCC827 cells. (a) Cells were exposed to 0.01 and 0.1 μmol/L icotinib for 24 h, and the cell cycle was analyzed by flow cytometry after staining with propidium iodide. (b) Expression of cell cycle proteins cyclins D1, A, and E was analyzed by Western blotting. β-Actin was used as the internal control. Data are representative of one of three independent experiments.