BioMed Research International / 2013 / Article / Tab 2

Research Article

Biological Activities of Phosphocitrate: A Potential Meniscal Protective Agent

Table 2

Differentially expressed genes in PC-treated via untreated OA meniscal cells.

Gene IDDifferential

FGF receptor signaling pathwayFGF9NM_0020102.38Fibroblast growth factor 9 (glia-activating factor)
FGFR2M877712.20Fibroblast growth factor receptor 2
FGF7NM_0020091.83Fibroblast growth factor 7 (keratinocyte growth factor)
NDST1AL5266321.71N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
THBS1AI8120301.68Thrombospondin 1
HHIPAK098525−3.28Hedgehog interacting protein
FGF18BC006245−1.73Fibroblast growth factor 18

Collagen fibril organizationCOL14A1M641082.06Collagen, type XIV, alpha 1
COL11A1J041771.82Collagen, type XI, alpha 1
COL1A1AI7436211.62Collagen, type I, alpha 1
SERPINH1NM_0043531.66Serpin peptidase inhibitor, clade H, member 1
TRAM2BC0281211.60Translocation-associated membrane protein 2
COL5A1AI9834281.52 Collagen, type V, alpha 1
COL5A2NM_0003931.44 Collagen, type V, alpha 2

Extracellular structure organizationCACNA1ANM_0230352.55Calcium channel, voltage dependent, P/Q type, alpha 1A subunit
COL14A1M641082.06Collagen, type XIV, alpha 1
ECM2NM_0013932.04Extracellular matrix protein 2, female organ, and adipocyte specific
MYO6AA8777891.98Myosin VI
TMPRSS6AI9120861.96Transmembrane protease, serine 6
COL11A1J041771.82Collagen, type XI, alpha 1
CRISPLD2AL1368611.74Cysteine-rich secretory protein LCCL domain containing 2
HSD17B12BC0125361.68Hydroxysteroid (17-beta) dehydrogenase 12
SERPINH1NM_0043531.66Serpin peptidase inhibitor, clade H, member 1
COL1A1AI7436211.62Collagen, type I, alpha 1
APLP1U484371.61Amyloid beta (A4) precursor-like protein 1
NFASCAI821777−1.99Neurofascin homolog (chicken)
MMP9NM_004994−1.91Matrix metallopeptidase 9

Inflammatory responseADORA1NM_0006742.48Adenosine A1 receptor
CD24L339302.09CD24 molecule
BCL6 S677791.98B-cell CLL/lymphoma 6
NGFNM_0025061.84Nerve growth factor (beta polypeptide)
CFDNM_0019281.82Complement factor D (adipsin)
ITGB2NM_0002111.80Integrin, beta 2
CFIBC0207181.74Complement factor I
NDST1AL5266321.71N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
IL17CAF1520991.70Interleukin 17C
THBS1AI8120301.68Thrombospondin 1
SERPINA3NM_0010851.67Serpin peptidase inhibitor, clade A, member 3
AGTR1NM_0048351.65Angiotensin II receptor, type 1
TFRCN763271.64Transferrin receptor (p90, CD71)
MASP1AI2740951.61Mannan-binding lectin serine peptidase 1
NFKBIZBE646573−2.58NFKb inhibitor, zeta
ANXA1AU155094−2.47Annexin A1
ADRB2NM_000024−2.41Adrenergic, beta-2, receptor, surface
SMAD1NM_015583−2.19SMAD family member 1
CXCL6NM_002993−2.19Chemokine (C-X-C motif) ligand 6
C2NM_000063−2.18Complement component 2
BMPR1BAA935461−1.93Bone morphogenetic protein receptor, type IB
TNFRSF1BNM_001066−1.74Tumor necrosis factor receptor superfamily, member 1B
EDNRANM_001957−1.67Endothelin receptor type A
PLA2G4AM68874−1.61Phospholipase A2, group IVA (cytosolic, calcium dependent)
GPR68AI805006−1.60G protein-coupled receptor 68

Negative number indicates decreased expression and positive number indicates elevated expression (fold change) in PC-treated OA meniscal cells compared with untreated OA meniscal cells.

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