Aldose Reductase Inhibitory Activity of Compounds from Zea mays L.
Table 2
Inhibitory effects of compounds isolated from the kernel of Zea mays L. on rat lens aldose reductase (RLAR).
Compounds
Concentration (μg/mL)
Inhibition (%)
IC50
(μg/mL)
(μM)
Protochatechuic acid (1)
10
3.22
>10
Vanillic acid (2)
10
20.34
>10
2,4,6-trihydroxybenzoic acid (3)
10
73.73
5
48.14
5.92
34.82
1
16.95
p-hydroxycinnamic acid (4)
10
77.81
5
43.73
6.02
36.71
1
13.76
Ferulic acid (5)
10
77.25
5
49.83
4.24
21.85
1
11.15
Hirsutrin (6)
10
86.69
5
76.15
2.22
4.78
1
27.56
3′-methoxyhirsutrin (7)
10
89.74
5
73.67
2.71
5.67
1
16.43
Cyanidin-3-glucoside (8)
40
47.72
>40
Pelargonidin-3-glucoside (9)
40
13.21
>40
Peonidin-3-glucoside (10)
40
36.98
>40
Cyanidin-3-(6′′-malonylglucoside) (11)
10
67.96
5
47.78
6.27
11.74
1
19.01
Pelargonidin-3-(6′′-malonylglucoside) (12)
10
NAb
>10
Quercetina
10
82.99
5
67.91
2.34
6.92
1
30.34
Inhibition rate was calculated as percentage with respect to the control value and expressed as mean of triplicate experiments. The concentration of each test sample giving rise to 50% inhibition of activity (IC50) was estimated from the least-squares regression line of the logarithmic concentration plotted against inhibitory activity. aQuercetin was used as positive control. bNA means nonactive.
