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BioMed Research International
Volume 2013, Article ID 734893, 12 pages
Clinical Study

Altered Functional Connectivity within and between Brain Modules in Absence Epilepsy: A Resting-State Functional Magnetic Resonance Imaging Study

1Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
2State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
3University of Chinese Academy of Sciences, Beijing 100039, China
4Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China

Received 28 April 2013; Revised 25 August 2013; Accepted 25 August 2013

Academic Editor: Andrei Surguchov

Copyright © 2013 Cui-Ping Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

A 1000-round permutation procedure was applied to correct for the multicomparison problem for the node-connection test. The distribution before and after sorting was presented in Figure S1. To confirm the pattern we found, we also present the differences between AE and normal with stricter threshold without multicomparison correction in Figure S2, or with smaller number of node-connections in Figure S3. Both of them showed similar patterns as the one described in the main text of the paper. To demonstrate that other frontal DMN nodes also showed the within-between-module diversity, the network generated by all frontal DMN nodes was presented in Figure S4 and the averaged value of functional connectivity was presented in Figure S5. The positive relations between epilepsy duration and within-between-module diversity is also true for all frontal DMN nodes, as shown in Figure S6. To exclude the possible confounds caused by the different age ranges of the AE and control group, data from another group of subjects age-matched to the AE patients were analyzed. We found a very similar pattern in the comparison of functional connection networks in Figure S7. In Figure S8, we also showed that the differential connectivity of orbital superior frontal gyrus is not significantly correlated with age in this control group.

  1. Supplementary Figure S1
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  3. Supplementary Figure S3
  4. Supplementary Figure S4
  5. Supplementary Figure S5
  6. Supplementary Figure S6
  7. Supplementary Figure S7
  8. Supplementary Figure S8