Suppression of Osteopontin Functions by Levocetirizine, a Histamine H₁ Receptor Antagonist, In Vitro

Figure 4

Influence of antihistamines on osteopontin (OPN)-induced GM-CSF production from nasal epithelial cells in vitro. Nasal epithelial cells obtained from five different subjects were stimulated with 250 ng/mL OPN in the presence of various concentrations of CT, LCT, DL and FEX for 24 h. GM-CSF levels in culture supernatants were examined by ELISA. *Significant (𝑃<0.05) versus OPN alone; (a) cetirizine (CT); (b) levocetirizine (LCT); (c) desloratadine (DL); (d) fexofenadine (FEX).

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