Low pH Environmental Stress Inhibits LPS and LTA-Stimulated Proinflammatory Cytokine Production in Rat Alveolar Macrophages
Figure 5
Effects of low pH stress on LPS-stimulated cytokine production in Ca2+-depleted (BAPTA-AM pretreatment) aMØs. Isolated aMØs were exposed to LPS and BAPTA-AM alone (LPS + BAPTA-AM) or in combination with low pH stress (LPS + BAPTA-AM + pH). Cytokines produced were assessed by ELISA (CINC-1, MIP-2, MCP-1, and INF-) or cytotoxicity bioassay (TNF-). LPS + BAPTA-AM versus LPS + BAPTA-AM + pH.