Hereditary Breast Cancer: The Era of New Susceptibility Genes

Table 1

Criteria of target population for genetic test on customized gene panel modified from (http://www.nccn.org/).

Individual with breast/ovarian cancer personal history and one of the following:
(i) breast and/or ovarian or pancreatic cancer in at least two blood relatives;
(ii) multiple primary breast cancers or bilateral breast cancer, first diagnosed before the age of 50 years;
(iii) premenopausal triple negative breast cancer diagnosed at a young age (<45 years);
(iv) male breast cancer in a blood relative;
(v) ethnicities with high BRCA mutation frequency, such as Ashkenazi Jews, should be tested, even in the absence of family history.