Increasing Affinity of Interferon-𝜸 Receptor 1 to Interferon-𝜸 by Computer-Aided Design

Table 1

Structural similarity of the IFN-𝛾 receptor molecules (IFN-𝛾-Rx) at and outside the interface with IFN-𝛾. Four receptor chains from crystal structures 1fg9 [17] and 1fyh [29] are compared to receptor chain D of 1fg9.

PDB	rmsd (Å)^a	rmsd (Å)^b
Code:chain	40 interface residues	40 random residues
1fg9:C	0.60	1.66
1fg9:E	4.16	4.32
1fyh:B	0.58	1.42
1fyh:E	0.59	1.06

aRoot mean square deviations (rmsd) between the four IFN-𝛾-Rx molecules (labeled PDB_ID:chain) and the chain D of 1fg9. Deviations are calculated between the positions of the main chain atoms of the 40 residues forming the interface with IFN-𝛾.
^bRoot mean square deviations (rmsd) between the four IFN-𝛾-Rx molecules (labeled PDB_ID:chain) and the chain D of 1fg9. Deviations are calculated between the positions of the main chain atoms randomly selected outside the 40 residues forming the interface with IFN-𝛾.