Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study
Table 4
Univariate analysis of various risk factors for infections with ESBL-producing organisms.
Variable
Neonates with acquisition of infections with ESBL-producing organisms ()
Neonates with acquisition of infections with non-ESBL-producing organisms ()
value
Relative risk (95% CI)
Birthweight (g)
1088 (825)
2253 (745)
0.001
—
Gestational age (weeks)
29 (3.24)
37 (4.15)
0.001
—
Birthweight < 1000 g (ELBW)
3 (38)
2 (11)
0.028
5.04 (0.94–150.82)
Preterm
7 (88)
13 (33)
0.005
0.11 (0.01–0.79)
Perinatal asphyxia
7 (88)
16 (41)
0.017
7.30 (0.97–54.83)
Mechanical ventilation > 7 days
5 (63)
10 (26)
0.041
0.28 (0.08–1.03)
Anemia
3 (38)
4 (10)
0.049
5.25 (0.67–43.39)
Metabolic acidosis
3 (38)
3 (8)
0.021
4.10 (1.30–12.91)
Respiratory distress syndrome
5 (63)
3 (8)
0.001
8.13 (2.42–27.32)
Central venous catheter duration (days)
12 (5.4)
2.4 (4.3)
0.001
—
PICC duration (days)
29 (13–35)
7 (0–12)
0.006
—
TPN duration (days)
26 (16–31)
7 (0–12)
0.001
—
Duration of hospital stay (days)
61 (39–91)
19 (11–21)
0.002
—
Duration of level 3 stay (days)
54 (35–77)
11 (7–22)
0.001
—
ESBL: extended-spectrum beta-lactamase; CI: Confidence interval; PICC: peripherally inserted central venous catheter; TPN: total parenteral nutrition. Univariate analysis of risk factors: only those with value < 0.05 are shown. Data are expressed as numbers (%), mean (standard deviation), and median (interquartile range).
