Research Article
Promoter Hypermethylation of the EMP3 Gene in a Series of 229 Human Gliomas
Table 4
Frequency of the molecular markers investigated with respect to the EMP3 methylation status.
| | Tumor type |
EMP3 methylation status (n) | IDH1/IDH2 mutations | MGMT methylation | EGFR amplification | Total 1p/19 codeletion | TP53 mutations | | n (%) | n (%) | n (%) | n (%) | n (%) |
| | PA | Methylated (4) | 0/4 (0) | 0/4 (0) | 1/3 (33.3) | 0/4 (0) | 0/4 (0) | | Unmethylated (14) | 1/14 (7.1) | 4/14 (28.6) | 1/10 (10) | 0/12 (0) | 3/14 (21.4) | | DA and GA | Methylated (3) | 3/3 (100) | 1/2 (50) | 0/3 (0) | 0/2 (0) | 2/3 (66.7) | | Unmethylated (6) | 1/6 (16.7) | 2/6 (33.3) | 0/6 (0) | 1/6 (16.7) | 2/5 (40) | | AA | Methylated (3) | 3/3 (100) | 1/1 (100) | 0/3 (0) | 0/3 (0) | 2/2 (100) | | Unmethylated (5) | 1/5 (20) | 1/4 (25) | 1/4 (25) | 0/2 (0) | 0/3 (0) | | pGBM | Methylated (5) | 0/5 (0) | 2/5 (40) | 2/4 (50) | 0/5 (0) | 1/4 (25) | | Unmethylated (57) | 0/53 (0) | 24/57 (42.1) | 21/54 (38.9) | 0/57 (0) | 12/38 (31.6) | | sGBM | Methylated (3) | 3/3 (100) | 3/3 (100) | 0/3 (0) | 0/3 (0) | 2/3 (66.7) | | Unmethylated (0) | — (—) | — (—) | — (—) | — (—) | — (—) | | OA | Methylated (9) | 9/9 (100) | 4/6 (66.7) | 0/6 (0) | 0/8 (0) | 4/6 (66.7) | | Unmethylated (3) | 1/3 (33.3) | 1/1 (100) | 0/1 (0) | 0/2 (0) | 1/1 (100) | | AOA | Methylated (5) | 3/5 (60) | 4/5 (80) | 1/5 (20) | 1/5 (20) | 1/1 (100) | | Unmethylated (3) | 1/1 (100) | 2/3 (66.7) | 1/1 (100) | 0/3 (0) | 1/1 (100) | | O | Methylated (33) | 29/33 (77.8) | 18/25 (13.3) | 1/29 (3.4) | 18/33 (54.5) | 5/19 (26.3) | | Unmethylated (9) | 5/9 (55.5) | 5/9 (55.9) | 1/9 (11.1) | 4/9 (44.4) | 1/5 (20) | | AO | Methylated (13) | 8/13 (61.5) | 9/13 (69.2) | 1/13 (7.7) | 8/13 (61.5) | 4/16 (40) | | Unmethylated (18) | 5/16 (31.2) | 12/16 (75) | 8/16 (50) | 3/16 (18.8) | 2/13 (15.4) |
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PA: pilocytic astrocytoma, DA: diffuse astrocytoma, GA: gemistocytic astrocytoma, AA: anaplastic astrocytoma, GBM: glioblastoma multiforme, O: oligodendroglioma, AO: anaplastic oligodendroglioma, OA: oligoastrocytoma, AOA: anaplastic oligoastrocytoma.
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