Molecular Imaging of Hepatocellular Carcinoma Xenografts with Epidermal Growth Factor Receptor Targeted Affibody Probes

Figure 6

Biodistribution of ⁶⁴Cu-DOTA-Z_EGFR∶1907 in nude mice bearing subcutaneous PLC/PRF/5 and Hep3B xenografts at 24 h. (a) Comparison of different organs in PLC/PRF/5 and Hep3B tumor-bearing animals after tail vein injection of ⁶⁴Cu-DOTA-Z_EGFR∶1907 (𝑛=3). (b) Comparison of tumor-to-blood (T/blood) and tumor-to-muscle (T/muscle) ratios in Hep3B and PLC/PRF/5 tumors (𝑛=3). (c) Comparison of different organs in PLC/PRF/5 tumor-bearing animals with (represented as PLC5 24 h B in figure) and without (represented as PLC5 24 h in figure) coinjection of unlabeled Ac-Cys-Z_EGFR∶1907 (𝑛=3).

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