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BioMed Research International
Volume 2013 (2013), Article ID 767496, 6 pages
Clinical Study

The Incidence of Hypogonadotropic Hypogonadism in Type 2 Diabetic Men in Polish Population

1Department of Internal Diseases, Diabetology and Endocrinology, Warsaw Medical University, Kondratowicza Street 8, 03-242 Warsaw, Poland
2Department of Endocrinology, Medical Centre for Postgraduate Education, Warsaw, Poland

Received 30 April 2013; Revised 27 August 2013; Accepted 16 September 2013

Academic Editor: Gabriel F. Anhe

Copyright © 2013 Michał Rabijewski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to investigate the incidence of hypogonadotropic hypogonadism (HH) in type 2 diabetic men (T2DM) in population of Polish men and examine the possible influence of estradiol levels and glycemic control. We evaluated TT, cfT, estradiol, and glycemic control (HbA1c) in 184 diabetic men and in 149 nondiabetic control group. The mean HbA1c was 8.6 ± 0.2% and 6.1 ± 0.3% and cfT concentration was 0.315 ± 0.08 nmol/L and 0.382 ± 0.07 nmol/L, respectively. T2DM had higher E2 concentration than nonobese control men (29.4 ± 3.7 pg/mL versus 24.5 ± 2.9 pg/mL). Forty-six percent of T2DM were hypogonadal and 93% had HH. We observed inverse relationship between BMI and cfT ( , ) and positive between BMI and E2 ( , ). E2 concentration was higher in T2DM with HH versus T2DM with normal TT/cfT concentration (34.5 ± 5.2 versus 27.4 ± 3.4 pg/mL). We observed negative correlation between HbA1c and cfT ( , ) but positive between HbA1c and E2 levels ( , ). The prevalence of obesity, hypertension, and CVD was higher in men with hypogonadism. High incidence of hypogonadotropic hypogonadism in type 2 diabetic men in Polish population is associated with poor glycemic control and can be secondary to an increase in estradiol concentrations.