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BioMed Research International
Volume 2013 (2013), Article ID 782067, 8 pages
http://dx.doi.org/10.1155/2013/782067
Research Article

Supplementation with Natural Forms of Vitamin E Augments Antigen-Specific TH1-Type Immune Response to Tetanus Toxoid

1Pathology Division, Faculty of Medicine and Health, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Wilayah Persekutuan, Malaysia
2Department of Nutrition, Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor Darul Ehsan, Malaysia

Received 8 April 2013; Accepted 10 June 2013

Academic Editor: Udai P. Singh

Copyright © 2013 Ammu Kutty Radhakrishnan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Sundram and A. A. Gapor, “Vitamin E from palm oil, its extraction and nutritional properties,” Lipid Technology, vol. 7, pp. 137–141, 1992. View at Google Scholar
  2. R. Loganathan, K. R. Selvaduray, K. Nesaretnam, and A. K. Radhakrishnan, “Health promoting effects of phytonutrients found in palm oil,” Malaysian Journal of Nutrition, vol. 16, no. 2, pp. 309–322, 2010. View at Google Scholar · View at Scopus
  3. K. Nesaretnam, S. Dorasamy, and P. D. Darbre, “Tocotrienols inhibit growth of ZR-75-1 breast cancer cells,” International Journal of Food Sciences and Nutrition, vol. 51, pp. S95–S103, 2000. View at Google Scholar · View at Scopus
  4. S. Khanna, S. Roy, H. Ryu et al., “Molecular basis of vitamin E Action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration,” Journal of Biological Chemistry, vol. 278, no. 44, pp. 43508–43515, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. C. K. Sen, S. Khanna, S. Roy, and L. Packer, “Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp(60c-Src) kinase activation and death of HT4 neuronal cells,” Journal of Biological Chemistry, vol. 275, no. 17, pp. 13049–13055, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. B. C. Pearce, R. A. Parker, M. E. Deason et al., “Inhibitors of cholesterol biosynthesis. 2. hypocholesterolemic and antioxidant activities of benzopyran and tetrahydronaphthalene analogues of the tocotrienols,” Journal of Medicinal Chemistry, vol. 37, no. 4, pp. 526–541, 1994. View at Google Scholar · View at Scopus
  7. S. N. Meydani, J. B. Blumberg, L. S. Leka et al., “Vitamin E supplementation and in vivo immune response in healthy elderly subjects: a randomized controlled trial,” Journal of the American Medical Association, vol. 277, no. 17, pp. 1380–1386, 1997. View at Google Scholar · View at Scopus
  8. S. N. Meydani, M. Meydani, C. P. Verdon, A. C. Shapiro, J. B. Blumberg, and K. C. Hayes, “Vitamin E supplementation suppresses prostaglandin E2 synthesis and enhances the immune response of aged mice,” Mechanisms of Ageing and Development, vol. 34, pp. 191–201, 1997. View at Google Scholar
  9. S. Moriguchi, N. Kobayashi, and Y. Kishino, “High dietary intakes of vitamin E and cellular immune functions in rats,” Journal of Nutrition, vol. 120, no. 9, pp. 1096–1102, 1990. View at Google Scholar · View at Scopus
  10. A. Bendich, E. Gabriel, and L. J. Machlin, “Dietary vitamin E requirement for optimum immune responses in the rat,” Journal of Nutrition, vol. 116, no. 4, pp. 675–681, 1986. View at Google Scholar · View at Scopus
  11. J.-Y. Gu, Y. Wakizono, Y. Sunada et al., “Dietary effect of tocopherols and tocotrienols on the immune function of spleen and mesenteric lymph node lymphocytes in Brown Norway rats,” Bioscience, Biotechnology and Biochemistry, vol. 63, no. 10, pp. 1697–1702, 1999. View at Google Scholar · View at Scopus
  12. T. R. Mosmann and R. L. Coffman, “TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties,” Annual Review of Immunology, vol. 7, pp. 145–173, 1989. View at Google Scholar · View at Scopus
  13. C. E. Samuel, “Antiviral actions of interferons,” Clinical Microbiology Reviews, vol. 14, no. 4, pp. 778–809, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. C.-S. Hsieh, S. E. Macatonia, C. S. Tripp, S. F. Wolf, A. O'Garra, and K. M. Murphy, “Development of T(H)1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages,” Science, vol. 260, no. 5107, pp. 547–549, 1993. View at Google Scholar · View at Scopus
  15. J. Magram, S. E. Connaughton, R. R. Warrier et al., “IL-12-deficient mice are defective in IFNγ production and type 1 cytokine responses,” Immunity, vol. 4, no. 5, pp. 471–481, 1996. View at Publisher · View at Google Scholar · View at Scopus
  16. A. K. Radhakrishnan, A. L. Lee, P. K. Wong, J. Kaur, J. Aung, and K. Nesaretnam, “Comparable effects on immune modulation following daily supplementation with tocotrienol-rich fraction (TRF) or alpha-tocopherol in normal human volunteers,” British Journal of Nutrition, vol. 101, no. 6, pp. 810–815, 2010. View at Google Scholar
  17. D. Mahalingam, A. K. Radhakrishnan, Z. Amom, N. Ibrahim, and K. Nesaretnam, “Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers,” European Journal of Clinical Nutrition, vol. 65, no. 1, pp. 63–69, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. M. A. Julie Westerink, S. Louise Smithson, N. Srivastava, J. Blonder, C. Coeshott, and G. J. Rosenthal, “ProJuvant (Pluronic F127/chitosan) enhances the immune response to intranasally administered tetanus toxoid,” Vaccine, vol. 20, no. 5-6, pp. 711–723, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. C. K. Sen, S. Khanna, and S. Roy, “Tocotrienols: vitamin E beyond tocopherols,” Life Sciences, vol. 78, no. 18, pp. 2088–2098, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. S. P. Yap, K. H. Yuen, and A. B. Lim, “Influence of route of administration on the absorption and disposition of α-, γ- and δ-tocotrienols in rats,” Journal of Pharmacy and Pharmacology, vol. 55, no. 1, pp. 53–58, 2003. View at Google Scholar · View at Scopus
  21. F. G. De Waart, L. Portengen, G. Doekes, C. J. Verwaal, and F. J. Kok, “Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects,” British Journal of Nutrition, vol. 78, no. 5, pp. 761–774, 1997. View at Publisher · View at Google Scholar · View at Scopus
  22. P. A. T. Sneath, E. G. Kerslake, and F. Scruby, “Tetanus immunity: the resistance of Guinea pigs to lethal spore doses induced by active and passive immunization,” The American Journal of Epidemiology, vol. 25, no. 3, pp. 464–476, 1937. View at Google Scholar · View at Scopus
  23. D. R. Vinson, “Immunisation does not rule out tetanus,” British Medical Journal, vol. 320, no. 7231, p. 383, 2000. View at Google Scholar · View at Scopus
  24. C.-Y. J. Lee and J. M.-F. Wan, “Vitamin E supplementation improves cell-mediated immunity and oxidative stress of asian men and women,” Journal of Nutrition, vol. 130, no. 12, pp. 2932–2937, 2000. View at Google Scholar · View at Scopus
  25. Z. Ren, M. Pae, M. C. Dao, D. Smith, S. N. Meydani, and D. Wu, “Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice,” Journal of Nutrition, vol. 140, no. 7, pp. 1335–1341, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Sakai and S. Moriguchi, “Long-term feeding of high vitamin E diet improves the decreased mitogen response of rat splenic lymphocytes with aging,” Journal of Nutritional Science and Vitaminology, vol. 43, no. 1, pp. 113–122, 1997. View at Google Scholar · View at Scopus
  27. T. R. Mosmann, J. H. Schumacher, N. F. Street et al., “Diversity of cytokine synthesis and function of mouse CD4+ T cells,” Immunological Reviews, no. 123, pp. 209–229, 1991. View at Google Scholar · View at Scopus
  28. Y. Wang and R. R. Watson, “Vitamin E supplementation at various levels alters cytokine production by thymocytes during retrovirus infection causing murine AIDS,” Thymus, vol. 22, no. 3, pp. 153–165, 1994. View at Google Scholar · View at Scopus
  29. K. Adachi, M. Miki, H. Tamai, M. Tokuda, and M. Mino, “Adipose tissues and vitamin E,” Journal of Nutritional Science and Vitaminology, vol. 36, no. 4, pp. 327–337, 1990. View at Google Scholar · View at Scopus
  30. A. Hosomi, M. Arita, Y. Sato et al., “Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs,” FEBS Letters, vol. 409, no. 1, pp. 105–108, 1997. View at Publisher · View at Google Scholar · View at Scopus
  31. D. E. Kaempf-Rotzoll, M. G. Traber, and H. Arai, “Vitamin E and transfer proteins,” Current Opinion in Lipidology, vol. 14, no. 3, pp. 249–254, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. D. H. Blatt, S. W. Leonard, and M. G. Traber, “Vitamin E kinetics and the function of tocopherol regulatory proteins,” Nutrition, vol. 17, no. 10, pp. 799–805, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. M. G. Traber and H. Arai, “Molecular mechanisms of vitamin E transport,” Annual Review of Nutrition, vol. 19, pp. 343–355, 1999. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Fairus, R. M. Nor, H. M. Cheng, and K. Sundram, “Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of α-tocopherol,” The American Journal of Clinical Nutrition, vol. 84, no. 4, pp. 835–842, 2006. View at Google Scholar · View at Scopus