BioMed Research International / 2013 / Article / Tab 1

Review Article

Cell Transplantation for Spinal Cord Injury: A Systematic Review

Table 1

In vivo transplantations of ESCs and iPSCs.

First authorYearSCI ModelsMain graftTransplantation methodsPre-differentiation or pretreatedCombinationTissue sparingNeuronal regenerationAxonal regeneration
/remyelination
Sensory functionMotor functionCavity and/or scare formationInflammationOthers

Bottai, [42]2010T8, contusion
-mice
Mouse ESCsi.v.Imp.Imp.Decreased nr. of macrophages and neutrophils
Kumagai, [43] 2009T10, contusion
-mice
Mouse ESCsLesion epicenter i. medu.Neurogenic neurospheresImp.No Imp.No Imp.No Imp.No angiogenesis
Mouse ESCsLesion epicenter i. medu.Gliogenic neurospheresImp.Imp.Imp.Imp.Enhanced angiogenesis
Lowry, [44]2008T8, dorsal
hemisection-mice
Mouse ESCsLesion site and rostral
i. medu.
Endothelial cells/hedgehog
/retinoci acid pre-treated
Imp.Imp.Imp.Imp.
Fujimoto, [45]2012T10, contusion
-mice
Human iPSCsLesion epicenter i. medu.Neuroepithelial-like stem cellsImp.Imp.Imp.Imp.
Chen, [46]2005T8, compression
-mice
Primed-hNSCsRostral and caudal
i. medu.
L1-transfectionImp.Imp.Imp.Imp.
Cui, [47]2011T9, compression
-mice
Mouse ESCsRostral and caudal
i. medu.
Neuronal differentiation and L1 expressionImp.Imp.Imp.Imp.Decreased microglial reaction
Perrin, [48]2010T9, compression
-rats
Human ESCsLesion site, rostral and caudal i. medu. Ngn2-transfectionNo Imp.Imp.Imp.Imp.
Hatami, [49]2009T10, lateral
hemisection-rats
Human ESCsLesion site, i. medu.Differentiated to NPsCollagen I
scaffold
Imp.Imp.Imp.
Niapour, [50]2012T9, contusion-ratsHuman ESCsLesion epicenter i. medu. Differentiated to NPsNPs + rat SCsImp.Imp.Imp.
Rossi, [51]2010C5-C6, contusion
-rats
Human ESCsventral horn,
rostral and caudal i. medu.
Differentiated to MPsImp.Imp.Imp.
Kim, [52]2010T13, lateral
hemisection-rats
Mouse ESCss. i.GABAergic differentiationImp.Increased evoked activity of WDR neurons
Keirstead, [53]2005T10, contusion
-rats
Human ESCsRostral and caudal
i. medu.
OPCs differentiationNo Imp.Imp.Imp.Imp.
Kerr, [54]2010T9, contusion-ratsHuman ESCsLesion site,
i. medu.
OPCs differentiationImp.Imp.Imp.Imp.Improved electrophysiological activities
Sharp, [55]2010C5, contusion-ratsHuman ESCsRostral and caudal
i. medu.
OPCs differentiationImp.Imp.Imp.Imp.Suppression of acute inflammation
Erceg, [56]2010T8, complete
transection-rats
Human ESCsRostral and caudal
i. medu.
OPCs and MPs differentiationOPCs + MPsImp.Imp.Imp.Improved electrophysiological activities
Salehi, [57]2009T9, complete
transection-rats
Human ESCsLesion site,
i. medu.
MNs differentiationMNs + OECsImp.Imp.Imp.Imp.Imp.

—: Not reported; Imp.: Improvement; i.v.: intravenously; i. medu.: intramedullary injection; s. i.: subarachnoid injection; SCI: spinal cord injury; NPs: neural precursors; OPCs: oligodendrocyte progenitor cells; MPs: motoneuron progenitors; MNs: motoneurons, SCs: Schwann cells; OECs: olfactory ensheathing cells.

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