BioMed Research International / 2013 / Article / Tab 2

Review Article

Cell Transplantation for Spinal Cord Injury: A Systematic Review

Table 2

In vivo transplantations of mesenchymal stem cells.

First authorYearSCI ModelsMain graftTransplantation methodsPre-differentiation or pretreatedCombinationTissue sparingNeuronal regenerationAxonal regeneration
/remyelination
Sensory functionMotor functionCavity and/or scare formationInflammationOthers

Nakajima, [58]2012T9-T10, contusion-ratsRats bMSCsLesion epicenter
i. medu.
Imp.Imp.Imp.Imp.Shifting of macrophage phenotype
Karaoz, [59]2012T9–T11, contusion-ratsRats bMSCsLesion epicenter
i. medu.
Imp.Imp.Only Nestin+/GFAP+ astrocytic-like cells were observed
Park, [60]2010T9, contusion-ratsRats bMSCsLesion epicenter
i. medu.
No Imp.more rapid restora-
tion*
Decreased nr. of macrophages and monocytesNo bladder function improvement
Abrams, [61]2009T11-12, contusion-ratsRats bMSCsLesion site, rostral and caudal
i. medu.
Partially Imp.Imp.Imp.Attenuated chronic inflammation
Kang, [62]2012T8–10, contusion-ratsRats bMSCsi.v.No Imp.Imp.
T8–10, contusion-ratsRats bMSCsRostral and caudal
i. medu.
NeuN+ differentiationImp.Expression of BDNF and NGF
Osaka, [63]2010T9, contusion-ratsRats bMSCsi.v.Imp.Imp.
Mothe, [64]2011T8-9, clip compression-ratsRats bMSCsi. thec.No Imp.Imp.
Boido, [65]2012T9, compressed-miceMice bMSCsLesion site,
i. medu.
Imp.No Imp.Imp.Imp.
Gu, [66]2010T9, contusion-ratsRats bMSCsRostral and caudal
i. medu.
Imp.No Imp.Imp.Imp.Imp.Imp.Expression of BDNF and GDNF
Alexanian, [67]2011T9, contusion-ratsHuman bMSCsRostral and caudal
i. medu.
Neural differentiationImp.Imp.No Imp.Imp.Imp.
Ban, [68]2011T9, contusion-ratsRats bMSCsLesion epicenter
i. medu.
MSCs + SCsImp.Imp.Imp.
Cho, [69]2009T9, contusion-ratsRats bMSCsLesion epicenter
i. medu.
Neural differentiationImp.Imp.Improvements in SSEPs and MEPs
Pedram, [70]2010T8-9, catheter compression-ratsRats bMSCsRostral and caudal
i. medu.
Neural differentiationDifferentiated and undifferentiated MSCsImp.Imp.
Liu, [71]2011T9, contusion-ratsRats bMSCsLesion epicenter
i. medu.
bFGF-transfectionImp.Imp.Imp.
Zhang, [72]2012T9, ethidium bromide-induced demyelination-ratsRats bMSCsLesion site,
i. medu.
NT-3-transfectionImp.Imp.Imp.Improvements in SCEPs
Zeng, [73]2011T8, complete transection-ratsHuman bMSCsLesion site,
i. medu.
Scaffolds + MSCsImp.Imp.Imp.Imp.Decreased nr. of macrophages and microglialEnhanced angiogenesis
Kang, [74]2012T8-9, complete removal of a 2-mm length of spinal cordHuman bMSCsLesion site,
i. medu.
Scaffolds + MSCsImp.Imp.Imp.Improvements in MEPs
Park, [75]2012L2-3 balloon catheter compression-dogsCanine aMSCsLesion site,
i. medu.
Neural differentiationMatrigel + neural-induced MSCsImp.Imp.Imp.Decreased expression of inflammation markersIncreased expression of neurotrophic markers
Guo, [76]2011T9, contusion-ratsHuman uMSCsLesion epicenter
i. medu.
Schwann-like cellsNT-3 + huMSC-derived Schwann-like cellsImp.Imp.
Shang, [77]2011T9, contusion-ratsHuman uMSCsLesion epicenter
i. medu.
NT-3-transfectionImp.Imp.Imp.Imp.
Lee, [78]2011L2-3 balloon catheter compression-dogsHuman uMSCsLesion site, rostral and caudal
i. medu.
Imp.Imp.Imp.Expression of BDNF and NT-4

More rapid restoration of hindlimb function without significant differences compared with control groups; —: Not reported; Imp., Improvement; i.v.: intravenously; i. medu.: intramedullary injection; i. thec.: Intrathecal implantation; SCI: spinal cord injury; SCs: Schwann cells; bMSCs: bone-marrow-derived Mesenchymal stem cells; aMSCs: canine adipose-derived mesenchymal stem cells; uMSCs: umbilical-cord mesenchymal stem cells.

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