Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013 (2013), Article ID 789679, 10 pages
Review Article

New Therapeutics in Promoting and Modulating Mandibular Growth in Cases with Mandibular Hypoplasia

17-020D Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, Canada T6G 2E1
2College of Dentistry, King Saud University, P.O. Box 60169, Riyadh 11545, Saudi Arabia

Received 13 January 2013; Revised 10 April 2013; Accepted 18 April 2013

Academic Editor: Brian L. Foster

Copyright © 2013 Tarek El-Bialy and Adel Alhadlaq. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Children with mandibular growth deficiency may develop airway obstruction. The standard treatment of severe airway obstruction involves invasive procedures such as tracheostomy. Mandibular distraction osteogenesis has been proposed in neonates with mandibular deficiency as a treatment option to avoid tracheostomy procedure later in life. Both tracheostomy and distraction osteogenesis procedures suffer from substantial shortcomings including scarring, unpredictability, and surgical complications. Forward jaw positioning appliances have been also used to enhance mandible growth. However, the effectiveness of these appliances is limited and lacks predictability. Current and future approaches to enhance mandibular growth, both experimental and clinical trials, and their effectiveness are presented and discussed.