Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients
Table 3
Multiple Cox regression analysis of obestatin, TNF-α, leptin, and IL-6 for predicting all-cause and cardiovascular mortalities.
Model 1
Model 2
Model 3
HR (95% CI)
HR (95% CI)
HR (95% CI)
All-cause mortality
Obestatin (<7.12 ng/mL)
2.44 (1.24–4.82)
0.010
2.47 (1.24–4.92)
0.010
2.46 (1.21–4.99)
0.013
TNF-α (<17.75 pg/mL)
0.75 (0.39–1.46)
0.40
0.75 (0.38–1.45)
0.39
1.16 (0.56–2.38)
0.69
Leptin (<16.7 ng/mL)
0.94 (0.49–1.78)
0.84
0.84 (0.44–1.62)
0.60
IL-6 (>6.4 pg/mL)
2.48 (1.20–5.13)
0.014
Cardiovascular mortality
Obestatin (<7.12 ng/mL)
4.06 (1.23–13.39)
0.021
4.14 (1.24–13.85)
0.021
3.63 (1.08–12.27)
0.038
TNF-α (<17.75 pg/mL)
0.98 (0.33–2.86)
0.97
0.97 (0.33–2.85)
0.95
1.64 (0.52–5.17)
0.40
Leptin (<16.7 ng/mL)
0.90 (0.32–2.51)
0.83
0.90 (0.31–2.56)
0.84
IL-6 (>6.4 pg/mL)
2.73 (0.86–8.71)
0.089
Obestatin, TNF-α, leptin, and IL-6 were categorized according to their median levels, as indicated. IL-6: interleukin-6; TNF-α: tumor necrosis factor-α; CI: confidence interval; HR: hazard ratio.
