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BioMed Research International
Volume 2013 (2013), Article ID 801769, 11 pages
Research Article

Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol

Department of Pharmaceutics, MAEER’s Maharashtra Institute of Pharmacy, MIT Campus, Survey No. 124, Kothrud, Pune, Maharashtra 411 038, India

Received 5 April 2013; Revised 19 August 2013; Accepted 24 September 2013

Academic Editor: Sandeep Nema

Copyright © 2013 Swati C. Jagdale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems of bisoprolol. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. The prepared system consisted of two parts: a core tablet containing the active ingredient and an erodible outer shell with gas generating agent. The rapid release core tablet (RRCT) was prepared by using superdisintegrants with active ingredient. Press coating of optimized RRCT was done by polymer. A 32 full factorial design was used for optimization. The amount of Polyox WSR205 and Polyox WSR N12K was selected as independent variables. Lag period, drug release, and swelling index were selected as dependent variables. Floating pulsatile release formulation (FPRT) F13 at level 0 (55 mg) for Polyox WSR205 and level +1 (65 mg) for Polyox WSR N12K showed lag time of 4 h with >90% drug release. The data were statistically analyzed using ANOVA, and was statistically significant. Release kinetics of the optimized formulation best fitted the zero order model. In vivo study confirms burst effect at 4 h in indicating the optimization of the dosage form.