Assessment of Hemodynamics in a Rat Model of Liver Cirrhosis with Precancerous Lesions Using Multislice Spiral CT Perfusion Imaging
Figure 2
The pathological images of normal and cirrhotic rat livers. (a) Tissue from normal rat livers. (b)-(c) Images of normal tissue with a higher magnification. Images showed typical lobular architecture and uniform distribution of liver cells. (d) Specimen of liver sample with low-grade DN. The liver showed gray surface and many nodules with various sizes. (e) Low-grade DN in a cirrhotic liver. (f) Image of low-grade DN with a higher magnification. Images showed increased number of cells with higher nuclei-to-cytoplasm ratio (black arrows). (g) High-grade DN in a cirrhotic liver. (h)-(i) Image of high-grade DN with a higher magnification. The reticular structure of nodule was reduced. Steatosis (arrow head) and clustered Mallory bodies (white arrow in (h)) of various sizes are found in the nodules (white arrow). Isolated adenoid structure was also found (arrow in (i)). Arrows indicated the ROI regions. Scale bar = 100 μM in (a) to (c) and (e) to (i).
