Differentially Methylated Loci Distinguish Ovarian Carcinoma Histological Types: Evaluation of a DNA Methylation Assay in FFPE Tissue

Figure 3

Scatter plots of β-values versus gene expression (log2 ratio) and Spearman correlation coefficients (𝑟²) from 543 serous ovarian carcinomas from The Cancer Genome Atlas. Two CpG loci were evaluated per gene. (a) and (b), ERG; (c) and (d), ISL1; (e) and (f), MST1R; (g) and (h), NRG1; (i) and (j), THSB2. β-values were not available for LY6G6E.

(a) 𝑟²=−0.07

(b) 𝑟²=−0.11

(c) 𝑟²=−0.08

(d) 𝑟²=0.02

(e) 𝑟²=−0.70

(f) 𝑟²=−0.65

(g) 𝑟²=−0.01

(h) 𝑟²=0.03

(i) 𝑟²=0.10

(j) 𝑟²=0.15