Differentially Methylated Loci Distinguish Ovarian Carcinoma Histological Types: Evaluation of a DNA Methylation Assay in FFPE Tissue

Table 3

Median β-values at selected genes^a in 543 serous ovarian carcinomas from The Cancer Genome Atlas.

Target gene^b	Chr	Coordinate, bp	CpG locus ID	Distance to TSS, bp^c	Location in promoter CGI^d	β-value	(Min., max.)
ERG	21	38955504	cg03127334	16	Yes	0.13	0.02, 0.88
ERG	21	38955762	cg17274064	27	No	0.11	0.02, 0.70
ISL1	5	50714208	cg21410991	81	Yes	0.24	0.02, 0.91
ISL1	5	50715118	cg26896762	9	Yes	0.07	0.02, 0.76
LY6G6E^e	6	—	—	—	—	—	—
MST1R	3	49915857	cg08687163	21	Yes	0.74	0.20, 0.97
MST1R	3	49916155	cg03332271	8	Yes	0.20	0.02, 0.91
NRG1	8	32524969	cg19162158	32	Yes	0.01	0.003, 0.72
NRG1	8	32525393	cg17457560	9	Yes	0.04	0.01, 0.76
THBS2	6	169395886	cg21652958	17	Yes	0.07	0.02, 0.81
THBS2	6	169396617	cg21732383	55	No	0.14	0.02, 0.93

aGenes found to be differentially methylated in the current study.
bAnnotation according to the Illumina Infinium Human DNA Methylation 27 assay.
cDistance in bp of CpG locus to transcription start site.
dCpG Island.
eβ-values not available in Illumina Infinium Human Methylation 27 K chip.