Tumor Necrosis Factor Receptor 2: Its Contribution to Acute Cellular Rejection and Clear Cell Renal Carcinoma
Figure 2
Tumour necrosis factor receptor-2 (TNFR2) mediated cellular responses in organ cultures of ACR. Treatment of cultures with a TNFR2-selective mutein induces TNFR2 mRNA and protein in tubular epithelial cells (arrows) (a, b), which in turn activates and phosphorylates epithelial/endothelial tyrosine kinase at tyrosine 40 (Etkp40) (c, d) promoting cell cycle entry, indicated by staining for proliferative cell nuclear antigen (PCNA) (e).
