Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model
Table 1
Number of animals with presence of major cardiac anomalies (by EKG) in DNA-immunized dogs with chronic experimental Chagas disease.
Group
Dogs/n (%)
Suggested pathological conditions by EKG features found [29, 30]
TcSP gene (pBCSP plasmid)
2/7 (29%)
AV block
1/7 (14%)
Left ventricular enlargement
TcSSP4 gene (pBCSSP4 plasmid)
1/7 (14%)
MIMI
1/7 (14%)
Second-degree AV block
pBK-CMV (empty plasmid)
6/7 (86%)
Most often abnormal when found on serial EKG and combined with other disturbances
4/7 (57%)
Left ventricle enlargement
1/7 (14%)
Right BBB
SS (mock-immunized)
3/7 (43%)
Most often abnormal if it is found on serial EKG and combinedwith other disturbances
1/7 (14%)
VPC
2/7 (29%)
Pericardial effusion
2/7 (29%)
Myocardial infarction and/or pericarditis and right ventricular enlargement
