Amylin Uncovered: A Review on the Polypeptide Responsible for Type II Diabetes

Table 1

Observed and predicted amyloid forming regions of amylin.

Year	Amyloidogenic region	Predicted or observed
1990 [35]	20–29	Observed
1999 [42]	17–34, 24–37, 30–37	Observed
2000 [43]	20–29	Observed
2000 [36]	23–27 and 22–27	Observed
2001 [44]	22–29	Observed
2001 [39]	8–20	Observed
2002 [38]	14–18, 14–22, 14–20, 15–20, 15–19	Observed
2002 [37]	22–27	Observed
2003 [45]	12–17, 15–20	Observed
2005 [40]	12–17, 22–27, 31–37	Observed
2006 [46]	13–18	Predicted
2007 [41]	8–17, 28–37	Predicted
2007 [47]	12–18, 15–20, 22–28	Predicted
2009 [48]	8, 13, 17, 25, 27, 32*	Predicted

*Nucleation sites.