BioMed Research International / 2013 / Article / Tab 1

Research Article

Development of a Novel System for Mass Spectrometric Analysis of Cancer-Associated Fucosylation in Plasma α1-Acid Glycoprotein

Table 1

Relative abundances of N-glycans with bi-, tri-, and tetra-antennary chains and their fucosylated ones in plasma AGP from healthy controls and colorectal cancer patients.

Relative abundance (%)#
Glycan structureNumbers of Normal CancerP value
[GlcNAc] [Fuc]( ) ( )

Bi-antennary2 036.12 ± 15.52 42.07 ± 14.03n.s.

3 0–247.10 ± 12.69 42.54 ± 13.03n.s.
Tri-antennary3 037.44 ± 12.57 25.84 ± 9.76<0.001
3 18.26 ± 3.63 14.60 ± 5.42<0.001
3 21.40 ± 1.05 2.10 ± 1.06<0.001
Fuc-tri-antennary3 1-29.66 ± 3.02 16.69 ± 5.42<0.001

4 0–315.03 ± 7.69 13.15 ± 4.08n.s.
4 07.95 ± 4.15 5.41 ± 2.19<0.001
Tetra-antennary4 11.42 ± 1.16 2.32 ± 1.30<0.001
4 20.57 ± 0.50 0.66 ± 0.57n.s.
4 30.29 ± 0.28 0.34 ± 0.36n.s.
Fuc-tetra-antennary4 1–32.28 ± 1.65 3.32 ± 1.82<0.01
5–7 0–61.63 ± 1.24 1.58 ± 0.91n.s.

Tri- + tetra-antennary 3–7 062.12 ± 17.09 55.69 ± 14.88n.s.
Fuc-(tri- + tetra-antennary)*3–7 1–618.68 ± 6.33 23.02 ± 5.7<0.001

based on the hit area to the total one. *FUCAGP: fucosylated (tri + tetra)-antennary glycans/total glycans × 100.

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