Modeling of the Renal Kinetics of the AT1 Receptor Specific PET Radioligand [¹¹C]KR31173

Table 5

Effect of imaging time on the distribution volume ratio DVR. The bias represented by the average % difference (for the 12 kidneys) between the actual DVR and reference DVR is acceptable (less than 10%) at time points 57.5 min or later. Loadings on factor 1 are acceptable (higher than 0.800) at time points 47.5 min or later.

Time point (min)	42.5	47.5	52.5	57.5	62.5	72.5	72.5	77.5	82.5	87.5
Bias (%)	66	25	16	7	5	4	1	1	1	0
Factor 1 loading	0.274	0.971	0.988	0.997	0.996	0.993	0.994	0.996	0.995	0.992
Factor 2 loading	0.961	0.125	0.018	−0.064	0.007	−0.071	−0.077	−0.050	−0.065	−0.085