Alleviation of Hyperglycemia Induced Vascular Endothelial Injury by Exenatide Might Be Related to the Reduction of Nitrooxidative Stress
The rats DM models had been successfully established and treatment with exenatide decreased fasting glucose levels in DM rats. (a) The changes of OGTT. High fat diet induced a significant increase in blood glucose levels in every time point. (b) Fasting insulin levels (FIns). High fat diet induced a significant increase in fasting insulin levels. (c) The changes of AUC. High fat diet induced a significant increase in AUC ( glucose). (d) HOMA insulin resistance (HOMA-IR). High fat diet induced a significant increase in HOMA-IR (HOMA-IR ( (mmol/L)/22.5). (e) Fasting glucose (FG) levels. DM induced a significant increase in fasting glucose levels, and treatment with exenatide for 45 days significantly decreased fasting glucose levels. In (a), (b), (c), and (d), CON and FD . In (e) CON ; DM, , and . ** versus CON; ## versus DM, mean ± SEM.
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