BioMed Research International / 2013 / Article / Fig 3

Research Article

Alleviation of Hyperglycemia Induced Vascular Endothelial Injury by Exenatide Might Be Related to the Reduction of Nitrooxidative Stress

Figure 3

Treatment with exenatide attenuated thoracic aortic histological changes in DM rats. (a) HE staining (×40). (b) vWF immunohistochemistry staining (×40). (c) Scanning electron microscopic observation (×500, ×1000, and ×3000). In DM group, the vascular endothelium and internal elastic membrane were severely damaged. There were less vWF positive particles and the continuity of the vWF positive thoracic aorta wall was interrupted. Endothelial cells were atrophic, cell junctions were damaged, moth-eaten injury was serious in cell membrane, mitochondria were swelling, lamellar cristae disappeared, and matrix was diluted. Treatment with exenatide improved the vascular endothelium in DM rats. Smooth muscle cells were almost normal in all groups.
843657.fig.003a
(a)
843657.fig.003b
(b)
843657.fig.003c
(c)

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.