Alleviation of Hyperglycemia Induced Vascular Endothelial Injury by Exenatide Might Be Related to the Reduction of Nitrooxidative Stress

Figure 5

Exendin-4 attenuated high glucose induced endothelial injury in vitro. (a) Highglucose induced a decreased cell viability of HUVECs. (b) Effect of different dose of exendin-4 on cell viability of HUVECs. (c) Exendin-4 pretreatment improved cell viability challenged with highglucose. (d) Exendin-4 pretreatment alleviated the increased TUNEL positive cells induced by highglucose. (e) Exendin-4 pretreatment alleviated the increased caspase-3 activity induced by high glucose. 𝑛 = 5~10. *𝑃<0.05, **𝑃<0.01 versus vehicle; ^#𝑃<0.05, ^##𝑃<0.01 versus G. G: 10 mM high glucose; 0.003E: 0.003 nM exendin-4; 0.03E: 0.03 nM exendin-4; 0.3E: 0.3 nM exendin-4.