Alleviation of Hyperglycemia Induced Vascular Endothelial Injury by Exenatide Might Be Related to the Reduction of Nitrooxidative Stress

Figure 6

Exendin-4 attenuated highglucose induced endothelial nitrooxidative stress in vitro. (a) Nitrotyrosine content in HUVECs. 𝑛=6. (b) MDA content in HUVECs. 𝑛=6. (c) iNOS expression in HUVECs. 𝑛=4. *𝑃<0.05, **𝑃<0.01 versus vehicle; ^#𝑃<0.05, ^##𝑃<0.01 versus G, mean ± SEM. G: 10 mM high glucose; 0.003E: 0.003 nM exendin-4; 0.03E: 0.03 nM exendin-4; 0.3E: 0.3 nM exendin-4.