Presymptomatic Treatment with Acetylcholinesterase Antisense Oligonucleotides Prolongs Survival in ALS (G93A-SOD1) Mice

Figure 2

Pre-symptomatic mEN101 treatment attenuates motor neuron death in the Tg-mice when compared to normal saline. At 15 weeks of age, mEN101 treated Tg-mice (𝑛=7) (b) had significantly higher MN counts/anterior horn section compared to the NS treated Tg-group (𝑛=5) (a) (𝑃<0.0002). A small group of Inv treated Tg-mice (c) also had higher MN counts (𝑛=3). The NS treated Tg-group (𝑛=5) (a) showed significantly lower MN counts than the NS treated WT mice (𝑛=12) (d) (𝑃<0.0001). Quantification results are presented in text. Dashed line in (d) indicates borders of the ventral horn. Magnification of MN in the ventral horn arrows indicate MNs. Scale bars = 50 μM.

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