BioMed Research International

Research Article

Molecular Profiling Predicts the Existence of Two Functionally Distinct Classes of Ovarian Cancer Stroma

Table 5

The unique compatible ligands and receptors from Table 4 showing the expression pattern in NS, CS1, CS2, and Cepi. The 6 bold signals had the same expression in NS and CS1 but different expression between CS1 and CS2 despite the fact that their compatible signals in Cepi were always expressed.
NSLigandsCS1CS2ReceptorsCepi
+CXCL12++CXCR4+
−FGF1++FGFR2−
−FGF1++FGFR3+
+FGF2+−FGFR3+
+FGF9++FGFR3+
−HGF++MET+
+PDGFA++PDGFRA+
+TGFB2++TGFBR2+
−IL7−+IL7R+
−WNT2++FZD2+
+WNT2B+−FZD2+
−WNT7A−+FZD7+
NSReceptorsCS1CS2LigandsCepi
+CXCR4++CXCL12+
+FGFR2++FGF1+
−FGFR3−+FGF1+
−FGFR3−+FGF9+
+PDGFRA++PDGFA+
+TGBFR2++TGFB2+
+IL1R1++IL1B+
−IL1R2+−IL1B+
+IL7R++IL7+
+FZD2++WNT2+
+FZD2++WNT2B+
+FZD7++WNT7A+
Expression is denoted with “+” (i.e., there is at least one Affymetrix present call with detection value ≤ 0.05) and nonexpression with “−” (i.e., there are no Affymetrix present calls in the samples with detection value ≤ 0.05).