TLR Stimulation of Bone Marrow Lymphoid Precursors from Childhood Acute Leukemia Modifies Their Differentiation Potentials

Table 1

Patient characteristics.

Patient	Age (y)	Sex	WBC/mm^3	Morphological diagnosis	Phenotype	BM blast infiltration (%)	Risk stratification	Risk factor
1	12	M	87,900	ALL-L2	B-ALL	88.9	HR	Leukocytosis; Age
2	2	F	12300	ALL-L1	B-ALL	80	SR	—
3	7	M	13800	ALL-L1	B-ALL	96	SR	—
4	7	F	157,000	ALL-L1	B-ALL	78.1	HR	Leukocytosis
5	10	M	70,700	ALL-L1	B-ALL	80	HR	Age; Leukocytosis
6	7	M	123,000	ALL-L2	B-ALL	98	HR	Leukocytosis
7	9	M	25,800	ALL-L2	B-ALL	98.5	SR	—
8	20	F	15,630	ALL-L1	B-ALL	80	HR	Age
9	13	M	211,000	ALL-L2	B-ALL	98	HR	Age; Leukocytosis
10	4	M	34,220	ALL-L1	B-ALL	90	SR	—
11	4 months	F	156,800	ALL-L1	C-ALL	94	HR	Age; Leukocytosis
12	7	M	17,400	ALL-L1	T-ALL	71.4	HR	T-cell phenotype
13	3	M	75,800	ALL-L1	T-ALL	89	HR	T-cell phenotype; No response to initial dexamethasone treatment; Leukocytosis; Positive cerebrospinal fluid
14	7	M	37,300	ALL-L2	M-ALL	94.2	HR	No response to initial dexamethasone treatment
15	13	M	200,000	ALL-L2	M-ALL	68	HR	Age; Leukocytosis
16	15	M	144,600	AML-M1	AML	94	HR	Leukocytosis

y: years old; WBC: white blood cell count; BM: bone marrow; M: male; F: female; B-ALL: B cell precursor acute lymphoblastic leukemia; T-ALL: T cell acute lymphoblastic leukemia; M-ALL: mixed acute leukemia; AML: Acute myeloid leukemia; C-ALL: congenital leukemia; HR: high risk; SR: standard risk.