Table 4: Pharmacological substances affecting the angiogenesis pathway found dysregulated by global gene expression profiling in diabetic retinopathy models. Presented are pharmacological substances having at least 20 or more associations with the angiogenesis pathway in the literature.

Subject Semantic relation Object Frequency

Endostatins Inhibits Angiogenesis 69
Thalidomide Inhibits Angiogenesis 37
Angiostatins Inhibits Angiogenesis 34
Curcumin Inhibits Angiogenesis 30
Bevacizumab Inhibits Angiogenesis 29
TNP 470 Inhibits Angiogenesis 23
Sphingosine 1-phosphate Affects Angiogenesis 22
Small molecule Inhibits Angiogenesis 22
Epigallocatechin gallate Inhibits Angiogenesis 21
Anti-inflammatory Agents, Nonsteroidal Inhibits Angiogenesis 16
Resveratrol Inhibits Angiogenesis 15