Table 6: Pharmacological substances with a potential stabilizing effect on genes differentially expressed in animal models of DR. Substances in bold are those occurring in both lists, concurrently stabilizing both upregulated and downregulated genes.

Therapeutic substanceNumber of downregulated genes in RD that are stimulated by the substance

Dexamethasone 19
Tretinoin 18
Ethanol 12
Phenylephrine 7
Curcumin 6
Hydroxymethylglutaryl-CoA reductase Inhibitors 6
Isoproterenol 6
Resveratrol 6

Therapeutic substanceNumber of upregulated genes in RD that are inhibited by the substance

Dexamethasone 14
Ethanol 14
Curcumin 10
Tretinoin 9
Small molecule 9
Epigallocatechin gallate 8
Rosiglitazone 8
PD 98059 7
Indomethacin 6
Propranolol 6
Quercetin 6