Integration of Data from Omic Studies with the Literature-Based Discovery towards Identification of Novel Treatments for Neovascularization in Diabetic Retinopathy
Table 6
Pharmacological substances with a potential stabilizing effect on genes differentially expressed in animal models of DR. Substances in bold are those occurring in both lists, concurrently stabilizing both upregulated and downregulated genes.
Therapeutic substance
Number of downregulated genes in RD that are stimulated by the substance
Dexamethasone
19
Tretinoin
18
Ethanol
12
Phenylephrine
7
Curcumin
6
Hydroxymethylglutaryl-CoA reductase Inhibitors
6
Isoproterenol
6
Resveratrol
6
Therapeutic substance
Number of upregulated genes in RD that are inhibited by the substance
