Vaccine Adverse Events Reported during the First Ten Years (1998–2008) after Introduction in the State of Rondonia, Brazil
Table 1
Distribution of reported adverse events and type of vaccine; Rondônia 1999–2008.
Event type
Vaccines
DTP
DTP/Hib
HB
MMR
YF
BCG
%
%
%
%
%
%
Systemic
Headache and vomiting
3
2.61
6
2.01
0
0.00
1
3.57
0
0
0
0.00
Afebrile seizure
2
1.74
9
3.02
1
3.23
0
0.00
0
0
0
0.00
Febrile seizure
19
16.52
37
12.42
1
3.23
0
0.00
0
0
0
0.00
Induration
2
1.74
4
1.34
3
9.68
0
0.00
1
5
0
0.00
Hypotonic hyporesponsive episodes
35
30.43
124
41.61
1
3.23
1
3.57
0
0
0
0.00
Generalized rash
2
1.74
12
4.03
3
9.68
8
28.57
4
20
0
0.00
Fever ≥39.5°C
30
26.09
52
17.45
1
3.23
2
7.14
0
0
1
4.17
Fever ≤39.5°C
1
0.87
16
5.37
1
3.23
3
10.71
1
5
1
4.17
Other serious events and/or unusual
2
1.74
8
2.68
3
9.68
1
3.57
0
0
0
0.00
Hypersensitivity reaction to 2 h
2
1.74
3
1.01
1
3.23
5
17.86
5
25
0
0.00
Hypersensitivity reaction after 2 h
4
3.48
6
2.01
0
0.00
2
7.14
5
25
0
0.00
Others
1
0.88
2
0.67
0
0.00
2
7.1
2
10
0
0.00
Local
Pain/redness/heat
4
3.48
7
2.35
0
0.00
0
0.00
1
5
0
0.00
Local hot abscess
4
3.48
2
0.67
13
41.94
1
3.57
0
0
0
0.00
Others
4
3.48
10
3.36
3
9.7
2
7.1
1
5
22
91.67
Total
115
100%
298
100%
31
100%
28
100%
20
100%
24
100%
Percentage (%) was calculated from the number of specific cases and total number of reported cases. Source: “ SI-EAPV do Programa de Imunizações do Estado de Rondônia” (EAPV Registry of Rondonia). BCG: Bacillus Calmette-Guérin; HB: hepatitis B; DTP+Hib: diphtheria-tetanus-pertussis+Hemophillus influenza b; DTP: diphtheria-tetanus-pertussis; MMR: mumps, measles, rubella; YF: yellow fever.
