p55PIK Transcriptionally Activated by MZF1 Promotes Colorectal Cancer Cell Proliferation
Figure 4
Transcriptional activation of p55PIK by MZF1 protein gives rise to cancer cell growth. Cells were transfected with a reporter plasmid for p55PIK promoter (−1243/+45)-p55PIK and cotransfected with or without MZF1-GFP expression plasmids or MZF1 SiRNA for 72 h to 96 h (a, b) Cell viability was detected with MTT assay as described under “Materials and Methods.” Data are shown as mean ± SD (n = 3; , per Student’s test).
