Chronic Stress Induces Structural Alterations in Splenic Lymphoid Tissue That Are Associated with Changes in Corticosterone Levels in Wistar-Kyoto Rats
Effect of stressors on body and adrenal gland weight and corticosterone levels in Wistar-Kyoto rats. Wistar-Kyoto rats (; per group) were treated with restraint stress (immobilization for 3 h daily) or hydrocortisone at 50 mg/kg or restraint stress plus hydrocortisone (mixed group) for 1, 4, and 7 weeks. (a) Body weight, (b) adrenal gland weight, and (c) corticosterone levels. Experimental groups showed significant differences compared to the control group at 1, 4, and 7 weeks of treatment. between immobilization and hydrocortisone groups; between immobilization and mixed groups; between mixed and hydrocortisone groups. Data are expressed as mean ± SE.