Evaluating the Importance of the Carotid Chemoreceptors in Controlling Breathing during Exercise in Man
Breathing matches metabolic rate, but with subtle deficits, after carotid chemoreceptor denervation in Man. 5–11 controls at 70% ( Wew) or 150% ( Wew) anaerobic (lactic acidosis) threshold and 5-6 carotid denervated subjects at 70% ( Wew) or 150% ( Wew) anaerobic threshold during constant load bicycle ergometry. (a) Mean ± se pH and PaCO2 in controls (open circle with filled line) and denervated (filled circle with dashed line). Mean resting PaCO2 in controls was mmHg and in denervated was mmHg. (b) Mean ± se minute ventilation per metabolic rate (/). ns , *versus 70% anaerobic threshold value for that condition. (c) Normalized minute ventilation as a percentage of total change in controls (open circle with filled line) and denervated (filled circle with dashed line) plotted against mean ± se minutes of exercise. (d) Average minute ventilation for percent of maximal for 1 min incremental cycle ergometer work test for 11 control and 6 denervated subjects. Vertical bars at each point are ± 1 se m. (e) PaCO2, bicarbonate , and pH changes in normal (top) and denervated (bottom) subjects at 0 Watts (filled circles) and at terminal () work rates for studies described above. Dashed arrows are averages for each group. Diagonal dashed lines are pH isopleths for -pCO2 buffer system. Reproduced with permission from Wasserman et al. .
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